CLSI C50

Mass Spectrometry in the Clinical Laboratory: General Principles and Guidance, 1st Edition

This guideline provides a general understanding of mass spectrometry and the principles that dictate its application in the clinical laboratory. It includes guidance, references, and quality assurance markers that will assist with the implementation and correct operation of a mass spectrometry (MS) system for its many applications. Information on maintaining optimum performance, approaches to ensuring accurate and precise mass measurement, verification of methods, quality control of assays within and between instruments, instrument troubleshooting, sample preparation, interpretation of results, and limitations of the technology is included.

This document is available in electronic format only.

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Chairholder: Donald H. Chace, PhD

Date of Publication: October 29, 2007

Order Code PDF: CLSI C50AE
ISBN Number: 1-56238-648-4

Order Code Print: print not available

Edition: First

Pages: 112

CLSI C50 Additional Details

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A CLSI-IFCC joint project.

This archived document is no longer being reviewed through the CLSI Consensus Document Development Process. However, this document is technically valid as of September 2017. Because of its value to the laboratory community, it is being retained in CLSI’s library.

CLSI C50 Abstract

Clinical and Laboratory Standards Institute document C50-A—Mass Spectrometry in the Clinical Laboratory: General Principles and Guidance; Approved Guideline provides a general understanding of MS and the principles that dictate its application in the clinical laboratory. It includes guidance, references, and quality assurance markers that will assist with the implementation and correct operation of an MS system for its many applications. Information on maintaining optimum performance, approaches to ensuring accurate and precise mass measurement, verification of methods, quality control of assays within and between instruments, instrument troubleshooting, sample preparation, interpretation of results, and limitations of the technology is included. This document is intended to be a basic resource for clinical chemists; health practitioners; instrument manufacturers; and those responsible for developing standards, implementing policy, and teaching.