CLSI C49

Analysis of Body Fluids in Clinical Chemistry, 2nd Edition

This guideline provides information for the medical laboratory for evaluating measurement procedures, as well as a strategy to characterize assay performance, when applied to body fluid matrixes. Key concepts that apply to the entire test cycle, including preexamination, examination, and postexamination phases of body fluid testing, are discussed.

This reaffirmed document has been reviewed and confirmed as suitable to remain published without revision to content, as of January 2023. The document’s next scheduled review is generally five years after the reaffirmation date.

This document is available in electronic format only.

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Chairholder: Deanna Franke, MT(ASCP), PhD, DABCC

Date of Publication: November 13, 2018

Order Code PDF: CLSI C49Ed2E
ISBN Number: 978-1-68440-024-9

Order Code Print: print not available

Edition: Second

Pages: 96

CLSI C49 Additional Details

A guideline for global application developed through the Clinical and Laboratory Standards Institute consensus process.

CLSI C49 Abstract

Clinical and Laboratory Standards Institute guideline C49—Analysis of Body Fluids in Clinical Chemistry provides guidance to the medical laboratory for evaluating measurement procedures, as well as a strategy to characterize assay performance, when applied to body fluid matrixes. Key concepts that apply to the entire test cycle, including preexamination, examination, and postexamination phases of body fluid testing are discussed. This guideline does not consider serum, plasma, whole blood, or fluids for which measurement procedures typically have performance claims in the measurement procedure documentation. Appendix A provides didactic content on the anatomy, physiology, and pathophysiology of fluid accumulation. Appendix B provides the medical rationale for quantifying measurands in body fluids and the interpretation of results in the context of disease. Appendix C provides the user with a quick reference guide to the suggested utility of fluid and measurand combinations.